For example, after infection with IAV, mPGES‐1 deficient macrophages exhibit an early increase in phospho‐IRF3, compared to wild‐type (WT) macrophages, augmented type I IFN, and decreased viral load, which was drastically inhibited by addition of exogenous PGE2 (Coulombe et al., 2014). The gene discussed is PTGES; the disease is infection.