IRF3 and infection: Infection with SARS‐CoV‐2 ligates various pathogen recognition receptors, for example, TLRs and/or RIG‐I‐like receptors, and activates transcription factors such as IFN regulatory factor 3 (IRF3) and NF‐κB that are responsible for expression of type I and III IFNs and proinflammatory mediators, including TNF‐α, IL‐6, and PGE2 respectively.