Finally, amplification of vascular endothelial growth factor A (VEGFA) [1, 17–20] and Fibroblast growth factor 19 (FGF19) gene [21, 22] predisposing to angiogenic and pro-proliferative signaling were found in 7–11% and 6.5% of HCC, respectively. This evidence concerns the gene FGF19 and hepatocellular carcinoma.