For this purpose, we aim to investigate the estrogen receptor genes (ER1, ER2, GPER), the glucocorticoid receptor (NR3C1) as well as the serotonin transporter (5-HTTLPR) and the respective relationships with a resilient menopausal transition or the development of depression in the perimenopause. The gene discussed is NR3C1; the disease is major depressive disorder.