For example, in a mouse model, excessive expression of URI in hepatocytes can lead to hepatocellular carcinoma (HCC) [85]; decreasing the expression of URI in the intestine will activate the c-Myc expression induced by β-catenin, leading to mouse cell proliferation, DNA damage, and susceptibility to fatal gastrointestinal syndrome (GIS) caused by ionizing radiation (IR) [88]. The gene discussed is MYC; the disease is hepatocellular carcinoma.