CCNA2 and colorectal cancer: In lung cancer, PFDN1 inhibits the expression of cyclin A by directly interacting with the cyclin A promoter at the transcription initiation site, thereby suppressing EMT and metastasis of lung cancer [36]; In colon cancer cell lines SW480 and RKO cells, silencing PFDN1 can inhibit the proliferation, invasion, and migration of colon cancer cells, and PFDN1 expression is positively correlated with tumor size and tumor invasion, therefore PFDN1 can be used as an indicator of poor prognosis of colorectal cancer [37].