SUV39H1 may be a prerequisite for promoter DNA methylation by recruiting DNMT3A, they cooperatively orchestrate epigenetic modification at the gene promoter regions of HAVCR2 and LGALS9. But HPV16 or 18 oncogenes didn’t affect the expression of H3K9me3 in cervical cancer cells. This evidence concerns the gene SUV39H1 and cervical cancer.