While BrdU+ proliferating cells in the control SVZ were neuronal-restricted progenitors with no p-Erk or Olig2 expression, BrdU+ proliferating cells in the mutant SVZ and in glioma precursor clusters from age-matched p53R172HCKO and p53∆E5–6CKO mice expressed Olig2 (Fig. 7f and Supplementary Fig. 8a)19. Here, OLIG2 is linked to central nervous system cancer.