IDH2 and malignant glioma: Furthermore, we found no somatic mutation in Idh1, Idh2, or H3f3a (mutated in pediatric GBMs) in malignant gliomas and GBMs from all three models, which were more similar to the human IDH-WT GBMs without exhibiting G-CIMP (Fig. 1g and Supplementary Fig. 1k, l)22,24.