For example, in the Type 2 case with the most complex chromosomal profile (Mouse 2), we validated three chromosomal events determined by WGS and SKY data: (1) 50% loss of chr16 in all tumor cells, (2) normal and loss of Pten/chr19 in SVZ- and parenchyma-derived tumors, respectively, and (3) acquisition of the founding cNRT2N, t(2;4), accompanied by loss of chr4, in all tumor cells except for 62.5% of SVZR-T-derived cells. The gene discussed is PTEN; the disease is neoplasm.