Together, all three Type 2 cases show that cNRT2N-1×-bearing FC-derived tumor precursor cells with near-2N genomes and normal Pten/chr19 (Mouse 3 has normal Pik3caH1047 allele) drive local evolution in the SVZ, while multiple clonally related progeny of the CA cell seed one distant site (“polyclonal seeding”) and/or one such progeny seeds multiple distant sites (“parallel seeding”), generating autologous cNRT2N-2×-bearing with sub-4N genomes and loss of Pten/chr19 (Mouse 3 has mutant Pik3caH1047R allele). This evidence concerns the gene PTEN and neoplasm.