We recently observed strong and monocyte-dependent costimulation of IFN-γ production in Vδ2T cells by TLR8 ligands, whereas proliferative expansion of Vδ2T cells in response to pAgs was simultaneously inhibited.220 Among the many translational perspectives, TLR/STING ligands are considered adjuvants for cancer vaccines.219,221 The intratumoral application of TLR222,223 and STING ligands224 may additionally be used to increase the inflammatory condition of the tumor in situ, thereby allowing more efficient migration of T cells, including γδ T cells, into the tumor microenvironment. The gene discussed is TLR8; the disease is neoplasm.