The remodeling of the extracellular matrix by an inhibitor of hyaluronan synthesis has been shown to enhance γδ T cell cytotoxicity against pancreatic adenocarcinoma cells in vitro and to promote the infiltration of γδ T cells into tumor tissue, thereby suppressing tumor growth in xenografted mice.218 Another strategy to enhance antitumor immunity is the activation of innate immunity by ligands for Toll-like receptors (TLRs) or cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING). The gene discussed is CGAS; the disease is pancreatic adenocarcinoma.