CD103-positive Vδ2T cells form prolonged synapses with E-cadherin-expressing tumor cells, and anti-CD103 antibodies reduced the killing capacity of TGF-β-expanded Vδ2T cells.159 The superior antitumor activity of tumor-specific CD8 αβ T cells expressing CD103 has been previously demonstrated.160,161 CD103 is a marker for resident memory cells, and CD103-positive TILs were associated with increased survival in high-grade serous ovarian cancer.162 CD103-expressing Vδ2T cells might migrate more efficiently into E-cadherin-positive tumor tissue. This evidence concerns the gene ITGAE and neoplasm.