These exciting new results also indicate that there might be the recruitment of an additional as yet unidentified CDR3 ligand upon complex formation of BTN2A1, BTN3A1, and pAgs.35,36 Recent results from J. Kuball’s group have added greater complexity to the molecular mechanisms involved in BTN-dependent tumor recognition by Vδ2T cells. This evidence concerns the gene BTN3A1 and neoplasm.