CD8A and cancer: Recently, it was shown that high-dose Vit C increased the efficacy of cancer immunotherapy in various mouse models by enhancing the cytotoxic activity of CD8 T cells and by cooperating with immune checkpoint inhibition.237 In fact, high-dose i.v. application of Vit C in cancer patients is used in some centers, and studies have shown a very good safety profile of high-dose Vit C therapy.238 Therefore, high-dose i.v. Vit C therapy might also be considered when thinking of ways to enhance the efficacy of γδ T cell therapy.