Multivariate analysis of factors related to OS included age (≥ 60 vs. < 60 years), AML types (non-M3 vs. M3), risk group (high vs. inter vs. low-risk), the time-dependent variable for allo-HSCT (yes vs.no), ASXL1 (mutated vs. wild type), RUNX1 (mutated vs. wild type), U2AF1 (mutated vs. wild type) and SF3B1 (mutated vs. wild type). The gene discussed is ASXL1; the disease is acute myeloid leukemia.