Genome-wide association studies (GWAS), conducted particularly in Caucasians, have identified single nucleotide variants (SNVs) associated with CM risk, many of which in human pigmentation genes, such as MC1R, solute carrier family 45 member 2 (SLC45A2) and tyrosinase (TYR)14–17. The gene discussed is SLC45A2; the disease is cutaneous mastocytosis.