To the best of our knowledge, there are no previous studies focusing the roles of ADCY3 c.675+9196T>G, CREB1 c.303+373G>A, and MITF c.938-325G>A SNVs in risk of CM, and therefore the association of CREB1 GA or AA genotype and allele “A” with CM risk seen in the present study is a new finding. This evidence concerns the gene MITF and cutaneous mastocytosis.