FANCM and breast cancer: Notably the PTCC had a FGFR3R248C pathogenic variant that is a recurring driver lesion for this tumor, while the TNBC had BRCA-like CNV features including high levels of interstitial aberrations and a somatic nonsense variant in FANCM. The latter has been identified as a breast cancer predisposition gene that confers an increased risk of TNBC20,21.