CTRL and Alzheimer disease: For example, in the PFC, Ctrl and AD mice show alterations in histidine metabolism (Fig. 3d,j), in the HPC changes are observed in glycine, serine, and threonine pathways (Fig. 3e,k), and in the spleen similarities are seen in the alanine, aspartate, and glutamate pathways (Fig. 3f,l).