ESCC-derived hypo-DMRs were enriched in genomic regions with heterochromatin markers such as H3K9me3 and H3K27me3, whereas hyper-DMRs were enriched in genomic regions with EZH2 or SUZ12 protein-binding sites (Fig. 2e, Supplementary Data File 3). This evidence concerns the gene EZH2 and esophageal squamous cell carcinoma.