Importantly, the gene expression levels of IKK-β and NF-Kβ (p50) in the hypothalamus of the mice with T2DM significantly decreased after they were treated with 80 mg/kg PSE (p < 0.05 and p < 0.05) and 140 mg/kg MET (p < 0.05). This evidence concerns the gene NFKB1 and type 2 diabetes mellitus.