The following observations indicated that PSE exhibited antidiabetic effects by inhibiting inflammation in the peripheral tissues and the central nervous system: changes in the LPS and pro-inflammatory cytokines in the plasma (Figure 8), changes in the pro-inflammatory cytokines at the gene expression and protein levels in the liver (Figures 9A and 9B) and adipose tissues (Figures 9C and 9D), and changes in IKK-β and NF-Kβ in the hypothalamus (Figure 10) of the mice with T2DM after the treatment with PSE. This evidence concerns the gene IKBKB and type 2 diabetes mellitus.