Confirming our previous data, we found that in tumors with M1hot TAMs compared with M1cold TAMs, the tumor-infiltrating CD8+ T cells showed increased expression of genes strongly enriched for TRM signature genes (eg, ITGAE, RBPJ) in addition to cell cycle and cytotoxic/cytokine signature genes (figure 6B, C). Here, CD8A is linked to neoplasm.