It is known that for survival in the tissues, TRM cells depend on uptake of essential nutrient fatty acids through FABP4/5.39 Also, it has been shown that macrophages treated with IL-4, (‘M1cold’), increase their fatty acid uptake.40 Hence, we hypothesized that M1cold TAMs will be more efficient than M1hot TAMs in competing for fatty acids in the tumor microenvironment (ie, due to higher expression of FABP3, 4, 5), and hence will outcompete TRM cells for this essential nutrient, thus compromising long-term maintenance of TRM cells in tumors. Here, IL4 is linked to neoplasm.