HLA-B*57, HLA-B*27, and HLA-B*52 are associated with a slow progression to AIDS (26, 27, 31, 33, –, 36), whereas HLA-B*35, HLA-B*58:02, and HLA-A*29:01-B*07:05-C*15:05 are associated with a rapid progression (28, 32, 34, 37, –, 40). The gene discussed is HLA-B; the disease is AIDS.