In addition, Gene Set Enrichment Analysis (GSEA) in gene expression profiles of colorectal cancer patients obtained from the TCGA database indicated that EMT pathway from the Molecular Signatures Database [23] and two published EMT gene signatures [24, 25] were significantly enriched in samples with high level of H19, demonstrated H19 is highly correlated with EMT signaling (Fig. 3b). Here, H19 is linked to colorectal cancer.