PTGS2 and breast neoplasm: In addition, breast tumor tissue overexpression of cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism and prostaglandin production, has been associated with markers of poor prognosis [35], while fatty acid synthase (FAS), a multi-enzyme complex that regulates de novo fatty acid synthesis, can provide proliferative and metastatic capacity to cancer cells and is also commonly overexpressed in breast cancer [36].