In addition, Choong et al. demonstrated that lncRNA-H19 and its interacting protein Y-box-binding protein-1 (YB-1) are involved in extracellular matrix (ECM) regulation during cardiac remodeling after infarction, and lncRNA-H19 directly antagonizes YB-1 under hypoxia, resulting in de-repression of Collagen 1A1 expression and cardiac fibrosis (Choong et al. 2019). The gene discussed is H19; the disease is infarction.