Patients with SARS-CoV-2 who manifest severe disease, including ARDS, multi-organ failure, and death, have higher plasma and BALF levels of inflammatory cytokines (‘cytokine storm’); higher plasma markers of coagulation, such as D-dimers; and increased prothrombin time and a lower platelet count [2, 8–11, 21–23]. This evidence concerns the gene F2 and acute respiratory distress syndrome.