MMP9 and cancer: In this study, we also verified that compared with human normal thyroid cell line HT-ori3, the protein expression level of MMP-9 in TC cell line (Fig. 1a), and mRNA expression level (Fig. 1c) were increased, which was consistent with the previous trend in tissue samples, suggesting that MMP-9 can be used as a potential biomarker of cancer, and its role as a therapeutic target in the fields of tumor diagnosis, therapeutic effect monitoring, and disease progression monitoring.