miR-221 could target suppressor of cytokine signalling-3 (SOCS3) and regulate apoptosis and proliferation via affecting JAK-STAT pathway, in bladder cancer [24]; inhibition of miR-221 alleviated LPS induced acute lung injury via inhibiting suppressor of cytokine signalling-1 (SOCS1) and apoptosis [25]; in WI-38 cells, downregulation of miR-221 resulted in relieved inflammatory damage via suppressing apoptosis [26]. Here, SOCS3 is linked to urinary bladder carcinoma.