Due to the abnormal activation of renin-angiotensin-aldosterone system (RAAS) and parathyroid hormone (PTH) of CKD, ANG II and PTH stimulate the coupled entry of Na + and lactate which in turn increase urate/lactate exchange across urate transporter 1 (URAT1) causing reduced uric acid excretion [9]. Here, SLC22A12 is linked to chronic kidney disease.