On the other hand, the lower abundance and TNF-α/IFN-γ cytokine response to PMA/ionomycin could also be a result of cell exhaustion in the observed Th, Tc, and NK cell populations [26–28] and/or Th2-skewing of T cell responses in the two allergy groups, as would be expected in particular for the IgEpos group [29]. This evidence concerns the gene TNF and allergic disease.