While in vitro experiments showed that IL-6 trans-signalling can overcome the repressive effects of trefoil factor 1 (TFF1) on IL-6 classic-signalling [68], gastric metaplasia induced by a hyperactive gp130 variant was not abrogated by a dimerised form of soluble gp130 (sgp130Fc) [69]. The gene discussed is IL6; the disease is Gastric Metaplasia.