CRP and inflammatory bowel disease: Taking into account the high prevalence of sleep impairment among patients with IBD identified in our study, as well as in other studies [14,15,21], and the significant association between sleep impairment and inflammatory parameters, we noticed a potential clinical benefit in identifying cut-off values for several parameters (PMN/Ly ratio, CRP/albumin ratio) that represent indirect measures of active disease as predictors of impaired sleep in patients experiencing a disease flare-up.