TP53 and neoplasm: In this context, the natural benzoquinone embelin (1) is an attractive molecule since displays a good number of biological activities such as antimicrobial [2], inhibition of X-chromosome-linked inhibitor of apoptosis protein (XIAPS) [3], inhibition of mortalin-p53 interactions, and activation of p53 protein in tumor cells [4], inhibition of 5-lipoxygenase [5], antitumoral activity via activation of p38/JNK pathway [6] and antidiabetic activity [7].