ITAM/ITIM-independent CTLs, such as the dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN/Clec4l/CD209) can also stimulate the activation of NF-κB via steroid receptor coactivator (SRC) and p21-activated kinase (PAK) or via the leukocyte-specific protein 1 (LSP-1), kinase suppressor of RAS 1 (KSR-1), and connector enhancer of kinase suppressor of RAS (CNK) rat sarcoma (RAS) signalosome [22]. Here, KSR1 is linked to sarcoma.