Other novel tissue-specific autoantibodies are currently under investigation: autoantibodies against salivary protein 1 (SP-1), parotid secretory protein (PSP) and carbonic anhydrase 6 have been described in pSS and non-pSS patients with chronic pain, which may help to understand and diagnose early pSS and pSS-associated widespread pain syndrome in the future [167]. Here, SP1 is linked to peeling skin syndrome.