ALDH1A3 and breast carcinoma: The citral has shown an antitumor effect on breast cancer cell lines such as MDA-MB-231 and MCF-7, in this case with G2/M phase cycle arrest and apoptosis induction [26]; likewise, citral was an effective aldehyde dehydrogenase 1A3 (ALDH1A3) inhibitor and capable of blocking the growth of the ALDH1A3-mediated breast tumor, potentially blocking its colony formation and gene expression regulation activity [41], but it also inhibited the growth of 4T1 breast tumors in Balb/c mice, although geranial (citral A) had a significant effect on mice induced with breast cancer 4T1 cell line [42].