Moreover, additional leukemia subtypes, including MLL-PTD, IDH1/2-, NPM1-, and DNMT3A-mutated subtypes, were found to be sensitive to DOT1L inhibition [17,18,19,20,21], strengthening the importance of DOT1L methyltransferase activity for leukemic cells irrespectively of MLL-r. Here, KMT2A is linked to leukemia.