After 7 days of co-cultured with tumor cells, NKG2DIL7-CAR T cells exhibited lower expression of PD-1 and Tim-3, especially in Tim3+ PD1+ expression (Figure 4c), suggesting that IL-7 could prevent CAR-T cell exhaustion and protect T cells from deleterious immunosuppressive actions of tumor cells. Here, HAVCR2 is linked to neoplasm.