PDCD1 and acute myeloid leukemia: In a phase I/II study (n = 51), a CR/CRi rate of 18% (6/35) with a median OS of 9.3 months (1.8-14.3 months) was shown in R/R AML patients with poor risk features (secondary AML, poor risk cytogenetics) who received nivolumab (anti-PD-1 antibody) and azacitidine approximately every 4–5 weeks indefinitely [110].