In a phase II trial of 65 FLT3-ITD-positive R/R AML patients treated with crenolanib as a single agent, there was an ORR of 50% (CRi 39%, partial remission (PR) 11%) among 18 patients who had not received prior FLT3 inhibitors and 31% (CRi 17%, PR 14%) among 36 patients who had received prior FLT3 inhibitors [32]. The gene discussed is FLT3; the disease is acute myeloid leukemia.