VKORC1 and obesity due to melanocortin 4 receptor deficiency: As obesity was also statistically significant in the previous model, we also assessed its interaction with mutations in the selected genes and noted that obesity interacted with CYP4F2 in the formation of femoral plaques and with either the presence of CYP4F2 or VKORC1 in the development of either carotid or femoral plaques.