Priapism has been reported as a rare side effect through direct inhibition of the sympathetic input necessary for detumesence.<h4>Presentation of case</h4>We describe an otherwise healthy man with recurrent and then persistent unresolved priapism after the use of tamsulosin and concomitant use of ace inhibitor and beta blocker for hypertension. The gene discussed is ACE; the disease is Hypertension.