Hsa_circ_0001649, a transcriptional product of the tumor suppressor gene SNF2 histone linker PHDRINGhelicase (SHPRH) (Wang et al. 2018), is a novel cancer-associated circRNA that exhibits decreased expression in several cancer types, including cholangiocarcinoma, hepatocellular carcinoma and colorectal cancer (Xing et al. 2018). This evidence concerns the gene SHPRH and cancer.