Although most studies have reported changes only in downstream circRNA expression during E2 action or ER knockout (Nair et al. 2016, Li et al. 2017b, Song et al. 2019, Yuan et al. 2019), one study showed that, in bladder cancer, ERα can regulate the expression of circ_0023642 by regulating the expression of its host gene UVRAG at the transcriptional level (Wu et al. 2019). This evidence concerns the gene ESR1 and urinary bladder carcinoma.