We also mapped various pathogenic mutations observed in neurofibromatosis type 1 diseases, which include L1208W, L1211R, D1217G, and deletion of M1215 at the N-terminal end, and L1490P, Q1494R/E, and G1498E at the C-terminal end of the GAPex region in NF1 (Figures S3A and S3E). This evidence concerns the gene NF1 and neurofibromatosis type 1.