NF1 and lung adenocarcinoma: In addition to neurofibromatosis type 1, the NF1 gene is often mutated in a variety of sporadic human malignancies, including glioblastoma, lung adenocarcinoma, acute myeloid leukemia, and ovarian and breast cancers (Blatt et al., 1986; Cancer Genome Atlas Research, 2008; Korf, 2000; Kresak and Walsh, 2016; Upadhyaya, 2011).