In a study of the effects of DFMO on cardiac hypertrophy in rats, DFMO not only inhibited ODC and decreased polyamine levels, but also decreased the expression of GRP78, protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), calreticulin, and caspase-12 [43]. The gene discussed is EIF2AK2; the disease is cardiac hypertrophy.