While it occurs in those without HIV-1 infection, herpes zoster ((HZ) is more common in PLWH in which it is more frequent in those with depressed blood CD4+ counts [39], but also occurs in untreated and treated PLWH at higher blood CD4+ T-cell counts than the more severe opportunistic infections defining an AIDS diagnosis [39, 40]. The gene discussed is CD4; the disease is HIV-1 infection.