Taken together, our data show that OCIAD1 is cleaved not only in heterologous expression systems but also in models of HCV infection as well as in the liver of patients with chronic hepatitis C. Moreover, our observations demonstrate that OCIAD1 is cleaved by NS3-4A derived from different HCV genotypes (1a, 1b, 2a, and 3a) represented by the Con1 and JFH1 cell culture adapted clones and the viruses circulating in the sera of patients included in this study. Here, KRAS is linked to chronic hepatitis C virus infection.