Extended genome-wide enrichment analysis showed that two of the CpGs (cg07839457 and cg17086398) mapped to genes (NLRC5 and SERINC2, respectively) previously associated with high-density lipoprotein cholesterol levels (FDR = 0.02) and alcohol dependence (FDR = 0.004) in genome-wide association studies (GWAS) analyses (Supplementary Table 16) [14]. The gene discussed is NLRC5; the disease is alcohol dependence.