To evaluate whether the predictive value of cyclin D1 expression for the prognosis of NPC is related with other clinicopathological features of NPC patients, we carried out multivariate analysis for age, histological type, lymph node metastasis, tumor stage, clinical stage, cyclin D1 negative expression, and positive expression. Here, CCND1 is linked to metastatic malignant neoplasm in the lymph nodes.