We found that the enforced expression of SIRT2 prominently suppressed SW620‐SIRT2 tumour metastasis compared with the SW620‐control group, while SW480‐shSIRT2 tumour‐bearing mice displayed increased metastasis in vivo, as evidenced by the bioluminescence signals, histological staining and survival analysis (Figure 3E,F). Here, SIRT2 is linked to neoplasm.