With recent efforts to identify biomarkers for sorting indolent PCa from fatal PCa, emerging genetic alternations associated with early onset PCa in younger patients were found including mutations in CTLA4, IDO1/TDO2, HOXB13, BRCA2, and TMPRSS2‐ERG fusion driven by androgen receptor.55, 56, 57, 58, 59, 60. This evidence concerns the gene HOXB13 and posterior cortical atrophy.