With recent efforts to identify biomarkers for sorting indolent PCa from fatal PCa, emerging genetic alternations associated with early onset PCa in younger patients were found including mutations in CTLA4, IDO1/TDO2, HOXB13, BRCA2, and TMPRSS2‐ERG fusion driven by androgen receptor.55, 56, 57, 58, 59, 60. The gene discussed is TDO2; the disease is posterior cortical atrophy.