Interestingly, it had shown that the steady growth of the prostate slowly accelerated at the age of 50 years,49 and after the age of 50 years, men's androgen levels could drop dramatically,50 and the aberrance of androgen/androgen receptor (AR) axis was well‐accepted to play a critical role in the development and progression of PCa.51 Here, AR is linked to posterior cortical atrophy.