Notably, this group of genes directly bound by PAX3/FOXO1, associated with SEs, and coregulated by KDM3A or/and Ets1, includes the following: known disease‐promoting genes in FP‐RMS (ALK, CCND2, FOXF1, IL‐4R, LOXL2, and MET) [1, 21, 22, 23, 24, 25]; other cancer‐promoting genes not previously studied in RMS (FGF8, PGF, and PODXL) [26, 27, 28, 29]; and MEST, a gene of poorly understood function upregulated in expression in RMS [30] (Fig. 3A). Here, MEST is linked to cancer.