Overexpression of S100A4 was correlated with age (> 50 vs. ≤50) (P=0.010, OR = 0.67, 95% CI: 0.49–0.91, I2 = 44.5%), tumor differentiation (poorly vs. well and moderately) (P<0.001, OR = 2.20, 95% CI: 1.69–2.85, I2 = 34.7%), LNM (yes vs. no) (P<0.001, OR = 3.70, 95% CI: 2.25–6.06, I2 = 79.3%), TNM stage (III/IV vs. I/II) (P<0.001, OR = 3.08, 95% CI: 2.10–4.53, I2 = 56.6%), and pathological subtype (ADC vs. SCC) (P=0.020, OR = 1.77, 95% CI: 1.09–2.88, I2 = 67.2%). Here, S100A4 is linked to neoplasm.