Additionally, overexpression of S100A4 was significantly correlated to patients’ age (OR = 0.67, 95% CI: 0.49–0.91, P=0.010), tumor differentiation (OR = 2.20, 95% CI: 1.69–2.85, P<0.001), lymph node metastasis (LNM) (OR = 3.70, 95% CI: 2.25–6.06, P<0.001), Tumor-Node-Metastasis (TNM) stage (OR = 3.08, 95% CI: 2.10–4.53, P<0.001), and pathological subtype (OR = 1.77, 95% CI: 1.09–2.88, P=0.020). Here, S100A4 is linked to neoplasm.