NTF3 and Charcot-Marie-Tooth disease type 1A: ,30 Liu et al. investigated the role of the NT3-TrkC pathway in myelination of Trembler-J mouse, a model of Charcot-Marie Tooth 1A (CMT1A), and observed that the injection of NT-3 decreased the myelin protein zero (P0) level in sciatic nerves.30