Furthermore, a previousstudy reported that E2F3 was down-regulated in HG-treated podocytes, anddownregulation of E2F3 could facilitate podocyte injury, indicating that E2F3 mightserve as a protective factor in DN (18).Nevertheless, whether E2F3 is involved in miR-770-5p knockdown-mediated improvementon podocytes is still unclear. This evidence concerns the gene E2F3 and liver dysplastic nodule.