As an important cytokine in cardiovascular diseases, the level ofIL-17A increased after ligation and reperfusion of the left coronary artery in mice.IL-17A knockout or treatment with anti-IL-17A monoclonal antibody significantlyattenuated I/R injury and improved cardiac function by reducing cardiomyocyteapoptosis and neutrophil infiltration (8). The gene discussed is IL17A; the disease is cardiovascular disorder.