In this study, we found immunohistochemical evidence of the protective effect of L-Ala-Gln on the internal pyramidal layer of the parietal area of gerbil brain tissue exposed to ischemia and reperfusion injuries based on the quantification of inflammation and cell activation biomarkers (TNF-α, NF-κB, IL-6 and HO-1). This evidence concerns the gene TNF and ischemia.