MDM from patients with PAD at baseline (V1) demonstrated significantly increased expression of tumor necrosis factor‐α, monocyte chemoattractant protein‐1, C‐X‐C motif chemokine 10, and IL‐10, and reduced expression of chemokine C‐C motif ligand 17, and mannose receptor C type 1 compared with healthy participants, consistent with a greater type 1 macrophage versus type 2 macrophage polarization in patients with PAD (Table S4). This evidence concerns the gene MRC1 and peripheral arterial disease.