NOS2 and peripheral arterial disease: Within the PAD cohort, a decrease in MDM gene expression of monocyte chemoattractant protein‐1 (expression fold change, 0.51±0.10; P=0.008), inducible nitric oxide synthase (expression fold change, 0.68±0.09; P=0.023), and C‐X‐C motif chemokine 10 (expression fold change, 0.25±0.06; P=0.043), all associated with the type 1 macrophage phenotype, occurred over the course of treatment.